mTOR Inhibitor

A mTOR Inhibitor is a inhibitor that inhibits mTOR.

• See: mTORC1, mTORC2, Immunosuppression, FKBP12, Drug Class, Mammalian Target of Rapamycin, Serine/Threonine-Specific Protein Kinase, Phosphoinositide 3-Kinase, Protein Complexes.

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References

2018

• (Wikipedia, 2018) ⇒ https://en.wikipedia.org/wiki/MTOR_inhibitors Retrieved:2018-7-13.
  • mTOR inhibitors are a class of drugs that inhibit the mammalian target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases (PIKKs). mTOR regulates cellular metabolism, growth, and proliferation by forming and signaling through two protein complexes, mTORC1 and mTORC2. The most established mTOR inhibitors are so-called rapalogs (rapamycin and its analogs), which have shown tumor responses in clinical trials against various tumor types.

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