Periplasmic Space

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A Periplasmic Space is a membrane space between the Inner Membrane and the Outer Membrane of a Cell.



  • (Wikipedia, 2009) ⇒
    • The periplasmic space or periplasm is a space between the inner cytoplasmic membrane and external outer membrane of Gram-negative bacteria or the equivalent space between the cell membrane and cell wall in Gram-positive bacteria. It may constitute up to 40% of the total cell volume in Gram-negative species, and is drastically smaller in Gram-positive. [1]
    • The space contains a loose network of murein (peptidoglycan) chains, as well as a gel containing hydrolytic and degradative enzymes. [2] Other enzymes in the gel are involved in various biochemical pathways including peptidoglycan synthesis, electron transport, and alteration of substances toxic to the cell (xenobiotic metabolism). [3] In some species, the gel also contains beta-lactamase, an enzyme responsible for degrading penicillin. This can be of clinical importance when considering antibiotic resistance.



  • MeSH:A.
    • The space between the inner and outer membranes of a cell that is shared with the cell wall."