Phospholipase

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A Phospholipase is an enzyme that Hydrolyzes Phospholipids into Fatty Acids and other Lipophilic Substances.



References

2009

  • (Wikipedia, 2009) ⇒ http://en.wikipedia.org/wiki/Phospholipase
    • A phospholipase is an enzyme that hydrolyzes phospholipids [1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D distinguished by what type of reaction they catalyze:
    Phospholipase A
         o Phospholipase A1 - cleaves the SN-1 acyl chain
         o Phospholipase A2 - cleaves the SN-2 acyl chain
    Phospholipase B - cleaves both SN-1 and SN-2 acyl chains, also known as a lysophospholipase.
    Phospholipase C - cleaves before the phosphate, releasing diacylglycerol and a phosphate-containing head group. Phospholipase Cs play a central role in signal transduction, releasing the second messenger Inositol triphosphate.
    Phospholipase D - cleaves after the phosphate, releasing phosphatidic acid and an alcohol.
      • Ontology: molecular function
      • Synonyms: None
    • Definition
Catalysis of the hydrolysis of a glycerophospholipid. [source: ISBN:0198506732]