Phospholipase C

A Phospholipase C is an enzyme produced within Cells.

• AKA: PLC.
• Context:
  • It can cleave Phospholipids (just before the Phosphate Group).
  • It can be activated in response to Growth Factor stimulation and Tyrosine Phosphorylation.
• Example(s):
  • Staphylococcus Aureus PLC http://www.uniprot.org/uniprot/P09978
  • Bacillus Cereus PLC http://www.uniprot.org/uniprot/P09598
  • PMID 4960932: “Enzymes capable of converting trypsinized normal or untreated filamentous whole cells and untreated envelopes to spheres included: lysozyme plus ethylenediaminetetraacetic acid, clostridial phospholipase C, and phospholipase D from cabbage”
• Counter-Example(s):
  • PMID 10361306: “We had previously reported that in B. thuringiensis expression of the phosphatidylinositol-specific phospholipase C gene is regulated by the transcriptional activator PlcR”
  • PMID 2820937: “The phospholipase C (PLC) gene of Pseudomonas aeruginosa encodes a heat-labile secreted hemolysin which is part of a Pi-regulated operon.”
• See: Eukaryotic Cell Physiology, Signal Transduction.

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References

• (Wikipedia, 2009) ⇒ http://en.wikipedia.org/wiki/Phospholipase_C
  • Phospholipase C is a class of enzymes that cleave phospholipids just before the phosphate group (see Figure). It is most commonly taken to be synonymous with the human forms of this enzyme, which plays an important role in eukaryotic cell physiology, particularly signal transduction pathways
• Gene Ontology http://amigo.geneontology.org/cgi-bin/amigo/term-details.cgi?term=GO:0004629&session_id=5828amigo1240506945
  • Accession: GO:0004629
  • Ontology: molecular function
  • Synonyms
    • related: lecithinase C activity
    • related: lipophosphodiesterase C
    • related: phosphatidase C
    • alt_id: GO:0042298
  • Definition
    • Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. [source: EC:3.1.4.3, EC:3.1.4.4, GOC:mah]

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