Chlortalidone
A Chlortalidone is a Thiazide-Like Diuretic Drug that is used to treat high blood pressure and certain edemas.
- Context:
- It can be used a High Blood Pressure Drug.
- It can also to treat edemas due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis.
- …
- Example(s):
- It can be used to prevent calcium-based kidney stones.
- It can be used to treatment nephrogenic diabetes insipidus.
- …
- Counter-Example(s):
- See: Thiazide-Like Diuretic, Hypertension, Edema, Hypokalemia.
References
2022
- (Wikipedia, 2022) ⇒ https://en.wikipedia.org/wiki/chlortalidone Retrieved:2022-5-22.
- Chlortalidone, also known as chlorthalidone, is a thiazide-like diuretic drug[1] used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis.[2][3] In high blood pressure it is a preferred initial treatment. It is also used to prevent calcium-based kidney stones. It is taken by mouth. Effects generally begin within three hours and last for up to three days. Chlortalidone is more effective than hydrochlorothiazide for prevention of heart attack or stroke.
Common adverse effects include low blood potassium, low blood sodium, high blood sugar, dizziness, and erectile dysfunction. Other adverse effects may include gout, low blood magnesium, high blood calcium, allergic reactions, and low blood pressure. Some reviews have found chlortalidone and hydrochlorothiazide to have a similar risk of adverse effects,[4] [5] while other reviews have found chlortalidone to have a higher risk. [6] While it may be used in pregnancy it is a less preferred option. How it works is not completely clear but is believed to involve increasing the amount of sodium and water lost by the kidneys. Chlortalidone was patented in 1957 and came into medical use in 1960. It is on the World Health Organization's List of Essential Medicines.[7] It is available as a generic medication. In 2019, it was the 135th most commonly prescribed medication in the United States, with more than 4million prescriptions.
- Chlortalidone, also known as chlorthalidone, is a thiazide-like diuretic drug[1] used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis.[2][3] In high blood pressure it is a preferred initial treatment. It is also used to prevent calcium-based kidney stones. It is taken by mouth. Effects generally begin within three hours and last for up to three days. Chlortalidone is more effective than hydrochlorothiazide for prevention of heart attack or stroke.
- ↑ Acelajado MC, Hughes ZH, Oparil S, Calhoun DA (March 2019). "Treatment of Resistant and Refractory Hypertension". Circ. Res. 124 (7): 1061–1070. doi:10.1161/CIRCRESAHA.118.312156. PMC 6469348. PMID 30920924. A long-acting thiazide-like diuretic, specifically chlorthalidone, if available, is recommended over hydrochlorothiazide (HCTZ) given its superior efficacy and clear benefit demonstrated in multiple outcome studies of hypertension.
- ↑ "Chlorthalidone Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 18 April 2019.
- ↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 229–230. ISBN 9780857113382.
- ↑ Dineva S, Uzunova K, Pavlova V, Filipova E, Kalinov K, Vekov T (November 2019). "Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide-meta-analysis". Journal of Human Hypertension. 33 (11): 766–774. doi:10.1038/s41371-019-0255-2. PMC 6892412. PMID 31595024.
- ↑ Roush GC, Abdelfattah R, Song S, Ernst ME, Sica DA, Kostis JB (October 2018). "Hydrochlorothiazide vs chlorthalidone, indapamide, and potassium-sparing/hydrochlorothiazide diuretics for reducing left ventricular hypertrophy: A systematic review and meta-analysis". Journal of Clinical Hypertension. 20 (10): 1507–1515. doi:10.1111/jch.13386. PMC 8030834. PMID 30251403.
- ↑ Springer K (December 2015). "Chlorthalidone vs. Hydrochlorothiazide for Treatment of Hypertension". American Family Physician. 92 (11): 1015–6. PMID 26760416.
- ↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.