D-Lactate Dehydrogenase

A D-Lactate Dehydrogenase is an enzyme that Catalyzes the Interconversion of Lactate and Pyruvate. It is widespread in Tissues and is abundant in Kidney, Skeletal Muscle, Liver, and Myocardium, appearing in elevated concentrations in the Blood when these tissues are injured.

• AKA: LDH.
• Context:
  • It can cleave Phospholipids (just before the Phosphate Group).
  • It can be activated in response to Growth Factor stimulation and Tyrosine Phosphorylation.
• Example(s):
  • Escherichia coli http://www.uniprot.org/uniprot/P06149
  • PMID 3882663: “ERecombinant DNA plasmids containing the gene for the membrane-bound D-lactate dehydrogenase (D-LDH ) of Escherichia coli linked to the promoter PL from lambda were constructed.”
• See: Escherichia Eoli (Strain K12).

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References

2009

• (Wikipedia, 2009) ⇒ http://en.wikipedia.org/wiki/D-lactate_dehydrogenase
  • Lactate dehydrogenase (LDH) is an enzyme (EC 1.1.1.27) present in a wide variety of organisms, including plants and animals.

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