DNA Replication Stress
A DNA Replication Stress is a stress on a genome.
- Context:
- It can include:
- Misincorporation of ribonucleotides
- Unusual DNA structures.
- Conflicts between replication and transcription
- Insufficiency of essential replication factors
- Common fragile sites.
- Overexpression or constitutive activation of oncogenes.
- Chromatin inaccessibility
- …
- It can include:
- Example(s):
- Counter-Example(s):
- See: DNA Replication, Chromosomal Fragile Site, Oncogene, Chromatin, Ataxia Telangiectasia Mutated, ATR-Chk1 Pathway, Fanconi Anemia Pathway, DNA Damage Response (DDR) Pathway.
References
2023
- (ChapGPT-OpenAI, 2023) ⇒ https://chat.openai.com/chat Retrieved:2023-03-26.
- Q: What is DNA Replication Stress?
- A: DNA replication stress refers to the conditions that disrupt the normal DNA replication process, leading to the accumulation of partially replicated or unreplicated DNA. This can be caused by various factors such as DNA damage, depletion of nucleotides, or interference with replication fork progression.
When DNA replication stress occurs, the cell activates a complex set of responses to prevent replication errors and maintain genomic stability. However, if the stress is severe or prolonged, it can lead to DNA damage and genomic instability, which can contribute to the development of cancer and other diseases.
Researchers have identified several molecular pathways that respond to DNA replication stress, including the ATR-Chk1 pathway, the Fanconi anemia pathway, and the DNA damage response (DDR) pathway. Understanding these pathways and their role in DNA replication stress is essential for developing new treatments for diseases associated with genomic instability.
2022
- (Wikipedia, 2022) ⇒ https://en.wikipedia.org/wiki/DNA_replication_stress Retrieved:2022-10-13.
- DNA replication stress refers to the state of a cell whose genome is exposed to various stresses. The events that contribute to replication stress occur during DNA replication, and can result in a stalled replication fork.
There are many events that contribute to replication stress, including:[1]
- Misincorporation of ribonucleotides
- Unusual DNA structures.
- Conflicts between replication and transcription
- Insufficiency of essential replication factors
- Common fragile sites.
- Overexpression or constitutive activation of oncogenes.
- Chromatin inaccessibility
- ATM and ATR are proteins that help to alleviate replication stress. Specifically, they are kinases that are recruited and activated by DNA damage.[2] The stalled replication fork can collapse if these regulatory proteins fail to stabilize it. When this occurs, reassembly of the fork is initiated in order to repair the damaged DNA end.
- DNA replication stress refers to the state of a cell whose genome is exposed to various stresses. The events that contribute to replication stress occur during DNA replication, and can result in a stalled replication fork.
- ↑ Zeman MK, Cimprich KA (January 2014). "Causes and consequences of replication stress". Nature Cell Biology. 16 (1): 2–9. doi:10.1038/ncb2897. PMC 4354890. PMID 24366029.
- ↑ Mazouzi A, Velimezi G, Loizou JI (November 2014). "DNA replication stress: causes, resolution and disease". Experimental Cell Research. 329 (1): 85–93.