Squalene Epoxidase Enzyme

A Squalene Epoxidase Enzyme is a flavin-containing microsomal monooxygenase enzyme.

• AKA: Squalene Monooxygenase, SQLE, SE Enzyme.
• Context:
  • It can typically catalyze Squalene Conversion to squalene epoxidase 2,3-epoxide product.
  • It can typically require Molecular Oxygen for squalene epoxidase oxidation reaction.
  • It can typically utilize FAD Cofactors in squalene epoxidase catalytic mechanism.
  • It can typically represent Committed Step in squalene epoxidase sterol synthesis.
  • It can typically localize to Endoplasmic Reticulum via squalene epoxidase membrane association.
  • ...
  • It can often serve as Antifungal Target for squalene epoxidase therapeutic inhibition.
  • It can often undergo Substrate-Induced Degradation by squalene epoxidase excess substrate.
  • It can often display Tissue-Specific Expression in squalene epoxidase metabolic tissues.
  • It can often participate in Cholesterol Feedback through squalene epoxidase transcriptional control.
  • ...
  • It can range from being a Basal Squalene Epoxidase Enzyme to being an Overexpressed Squalene Epoxidase Enzyme, depending on its squalene epoxidase expression level.
  • It can range from being a Sensitive Squalene Epoxidase Enzyme to being a Resistant Squalene Epoxidase Enzyme, depending on its squalene epoxidase inhibitor response.
  • ...
  • It can function within Cholesterol Biosynthesis Processes as squalene epoxidase post-squalene enzyme.
  • It can connect to Mevalonate Pathways through squalene epoxidase downstream position.
  • It can interface with Lanosterol Synthesis Processes via squalene epoxidase product conversion.
  • It can interact with Cytochrome P450 Reductases for squalene epoxidase electron transfer.
  • It can respond to SREBP Regulation Systems through squalene epoxidase gene control.
  • ...
• Example(s):
  • Squalene Epoxidase Enzyme Types, such as:
    • Mammalian Squalene Epoxidase Enzymes, such as:
      • Human Squalene Epoxidase Enzyme with squalene epoxidase terbinafine sensitivity.
      • Mouse Squalene Epoxidase Enzyme for squalene epoxidase research models.
    • Fungal Squalene Epoxidase Enzymes, such as:
      • Candida Squalene Epoxidase Enzyme as squalene epoxidase antifungal target.
      • Dermatophyte Squalene Epoxidase Enzyme in squalene epoxidase therapeutic application.
  • Squalene Epoxidase Enzyme Variants, such as:
    • Wild-Type Squalene Epoxidase Enzyme with squalene epoxidase normal function.
    • Mutant Squalene Epoxidase Enzyme with squalene epoxidase altered activity.
  • ...
• Counter-Example(s):
  • Squalene Synthase Enzymes, which produce rather than oxidize squalene molecules.
  • Lanosterol Synthase Enzymes, which cyclize rather than epoxidize substrate molecules.
  • Cytochrome P450 Enzymes, which perform monooxygenation but not squalene epoxidation.
• See: Monooxygenase Enzyme, Cholesterol Biosynthesis Process, Squalene Molecule, Lanosterol Synthesis, Antifungal Drug Target.

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