Staphylokinase
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Staphylokinase is a Bacterial Kinase produced by certain strains of Staphylococci; it induces Fibrinolysis by converting Plasminogen to Plasmin.
- AKA: SAK.
- Context:
- It can cleave IgG and complement component C3b, inhibiting phagocytosis.
- Example(s):
- Staphylococcus Aureus http://www.uniprot.org/uniprot/P68802
- PMID 11779212: “Streptokinase (SKe) produced by Streptococcus equisimilis and staphylokinase
secreted from Staphylococcus aureus are human plasminogen activators and streptokinase (SKu), produced by Streptococcus uberis, is a bovine plasminogen activator.”
- See: Staphylococcus Aureus.
References
- (Wikipedia, http://en.wikipedia.org/wiki/Staphylokinase
- Staphylokinase (SAK) is a amino acid enzyme from Staphylococcus aureus. [1]It is positively regulated by the "agr" gene regulator.
It activates plasminogen to form plasmin, which digest fibrin clots. This disrupts the fibrin meshworkwhich can often form to keep an infection localized.
- Staphylokinase also cleaves IgG and complement component C3b, inhibiting phagocytosis.
- It is classified under EC 3.4.99.22.