Angiotensin-Converting Enzyme (ACE)

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An Angiotensin-Converting Enzyme (ACE) is an enzyme that is a core component of the Renin-Angiotensin System (RAS) that controls blood pressure by regulating the volume of fluids in the body.



References

2020

  1. Kaplan's Essentials of Cardiac Anesthesia. Elsevier. 2018. doi:10.1016/c2012-0-06151-0. ISBN 978-0-323-49798-5. “ Mechanisms of Action:ACE inhibitors act by inhibiting one of several proteases responsible for cleaving the decapeptide Ang I to form the octapeptide Ang II. Because ACE is also the enzyme that degrades bradykinin, ACE inhibitors increase circulating and tissue levels of bradykinin (Fig. 8.4)".
  2. Skeggs LT, Kahn JR, Shumway NP (Mar 1956). "The preparation and function of the hypertensin-converting enzyme". The Journal of Experimental Medicine. 103 (3): 295–9. doi:10.1084/jem.103.3.295. PMC 2136590. PMID 13295487.
  3. Hemming ML, Selkoe DJ (November 2005). "Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor". The Journal of Biological Chemistry. 280 (45): 37644–50. doi:10.1074/jbc.M508460200. PMC 2409196. PMID 16154999.