- AKA: Periplasmic Space.
- See: Cellular Component.
- (Wikipedia, 2009) ⇒ http://en.wikipedia.org/wiki/Periplasm
- The periplasmic space or periplasm is a space between the inner cytoplasmic membrane and external outer membrane of Gram-negative bacteria or the equivalent space between the cell membrane and cell wall in Gram-positive bacteria. It may constitute up to 40% of the total cell volume in Gram-negative species, and is drastically smaller in Gram-positive. 
- The space contains a loose network of murein (peptidoglycan) chains, as well as a gel containing hydrolytic and degradative enzymes.  Other enzymes in the gel are involved in various biochemical pathways including peptidoglycan synthesis, electron transport, and alteration of substances toxic to the cell (xenobiotic metabolism).  In some species, the gel also contains beta-lactamase, an enzyme responsible for degrading penicillin. This can be of clinical importance when considering antibiotic resistance.
- Gene Ontology http://amigo.geneontology.org/cgi-bin/amigo/term-details.cgi?term=GO:0042597&session_id=5828amigo1240506945
- Accession: GO:0042597
- Ontology: cellular component
- exact: periplasm
- alt_id: GO:0005620
- The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or inner membrane and cell wall (Fungi). [source: GOC:go_curators].
- "The space between the inner and outer membranes of a cell that is shared with the cell wall."