Hepatocyte

A Hepatocyte is a specialized epithelial cell.

• AKA: Liver Cell, Hepatic Parenchymal Cell, Liver Epithelial Cell.
• Context:
  • It can typically constitute Liver Tissue with hepatocyte proportions of 80%.
  • It can typically perform Metabolic Processes including hepatocyte cholesterol biosynthesis.
  • It can typically produce Plasma Proteins through hepatocyte protein synthesis.
  • It can typically synthesize Bile Acids from hepatocyte cholesterol metabolism.
  • It can typically store Glycogen Molecules for hepatocyte energy regulation.
  • ...
  • It can often detoxify Xenobiotic Compounds via hepatocyte enzyme systems.
  • It can often regenerate Liver Tissue through hepatocyte proliferation.
  • It can often maintain Glucose Homeostasis by hepatocyte gluconeogenesis.
  • It can often secrete Lipoprotein Particles containing hepatocyte-produced lipids.
  • ...
  • It can range from being a Periportal Hepatocyte to being a Pericentral Hepatocyte, depending on its hepatocyte zonation location.
  • It can range from being a Quiescent Hepatocyte to being a Proliferating Hepatocyte, depending on its hepatocyte cell cycle state.
  • It can range from being a Healthy Hepatocyte to being a Diseased Hepatocyte, depending on its hepatocyte pathological condition.
  • ...
  • It can host Cholesterol Biosynthesis Processes for hepatocyte lipid production.
  • It can express HMG-CoA Reductase Enzymes for hepatocyte cholesterol regulation.
  • It can contain Mevalonate Pathways in hepatocyte cytoplasm.
  • It can utilize Squalene Epoxidase Enzymes for hepatocyte sterol synthesis.
  • It can implement Feedback Inhibition Mechanisms for hepatocyte metabolic control.
  • ...
• Example(s):
  • Hepatocyte Functional Types, such as:
    • Zone 1 Hepatocytes, such as:
      • Oxidative Metabolism Zone 1 Hepatocyte for hepatocyte oxygen-rich processing.
      • Gluconeogenic Zone 1 Hepatocyte for hepatocyte glucose production.
    • Zone 3 Hepatocytes, such as:
      • Glycolytic Zone 3 Hepatocyte for hepatocyte anaerobic metabolism.
      • Drug Metabolism Zone 3 Hepatocyte for hepatocyte xenobiotic processing.
  • Hepatocyte Developmental Stages, such as:
    • Fetal Hepatocyte with hepatocyte hematopoietic function.
    • Adult Hepatocyte with hepatocyte mature metabolic capability.
    • Senescent Hepatocyte with hepatocyte reduced regenerative capacity.
  • ...
• Counter-Example(s):
  • Kupffer Cells, which are liver macrophages rather than metabolic epithelial cells.
  • Cholangiocytes, which line bile ducts rather than perform hepatocyte metabolism.
  • Stellate Cells, which store vitamin A rather than conduct hepatocyte functions.
• See: Specialized Epithelial Cell, Liver Cell, Cholesterol Biosynthesis Process, Metabolic Cell, Bile Acid Biosynthesis Process, Detoxification Process.

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