2006 HumanGeneNameNormalUsingTextMatching

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Subject Headings: Gene Mention Normalization Algorithm.

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Abstract

The identification of genes in biomedical text typically consists of two stages: identifying gene mentions and normalization of gene names. We have created an automated process that takes the output of named entity recognition (NER) systems designed to identify genes and normalizes them to standard referents. The system identifies human gene synonyms from online databases to generate an extensive synonym lexicon. The lexicon is then compared to a list of candidate gene mentions using various string transformations that can be applied and chained in a flexible order, followed by exact string matching or approximate string matching.

Using a gold standard of MEDLINE abstracts manually tagged and normalized for mentions of human genes, a combined tagging and normalization system achieved 0.669 F-measure (0.718 precision and 0.626 recall) at the mention level, and 0.901 F-measure (0.957 precision and 0.857 recall) at the document level for documents used for tagger training.



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 AuthorvolumeDate ValuetitletypejournaltitleUrldoinoteyear
2006 HumanGeneNameNormalUsingTextMatchingKevin P. Murphy
Yang Jin
Peter S. White
Haw-ren Fang
Jessica S. Kim
Human Gene Name Normalization Using Text Matching with Automatically Extracted Synonym DictionariesProceedings of the BioNLP Workshop on Linking Natural Language Processing and Diologyhttp://aclweb.org/anthology/W/W06/W06-3306.pdf2006