2x2 Crossover Experiment

A 2x2 Crossover Experiment is a crossover experiment that is a two treatment experiment and a two period experiment.

• Context:
  • It can range from being a Fully Randomized 2x2 Crossover Experiment to being a Cluster Randomized 2x2 Crossover Experiment.
  • It can range from being a Categorical Outcome 2x2 Crossover Experiment to being a Continuous Outcome 2x2 Crossover Experiment.
  • It can result in a 2x2 Crossover Experiment Dataset that can be analyzed by a 2x2 Crossover Experiment Evaluation Task.
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• Example(s):
  • a Continuous Outcome Cluster Randomized 2x2 Crossover Experiment, such as a eEPC Lift Cluster Randomized 2x2 Crossover Experiment.
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• Counter-Example(s):
  • a Multi-Period Crossover Experiment.
  • a Single-Period Randomized Experiment.
  • a Factorial Randomized Experiment.
• See: Crossover Experiment.

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References

2011

• Looney SM, Raynor HA. Impact of portion size and energy density on snack intake in preschool-aged children. In: J Am Diet Assoc 2011;111.

2003

• (Jones & Kenward, 2003) ⇒ Byron Jones, and Michael G Kenward. (2003). “Design and Analysis of Cross over Trials." CRC Press. ISBN:0412606402
  • QUOTE: The simplest design is the two-period two-treatment or 2×2 design. In this design each subject receives two different treatments which we conventionally label as A and B. Half the subjects receive A first and then, after a suitably chosen period of time, cross over to B. The remaining subjects receive B first and then cross over to A. A typical example of such a trial is given in Example 1.1.

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