Clinical Efficacy Measure
A Clinical Efficacy Measure is a clinical trial measure for the general ability of clinical intervention to achieve a therapeutic effect in an ideal setting, such as a research laboratory study.
- Context:
- It can be evaluated by an Efficacy Clinical Trial.
- It can (typically) be related to Clinical Efficacy.
- It can be evaluated by an Effectiveness Clinical Trial.
- It relates to how well a treatment works in practice, as it can be shown in pragmatic clinical trials.
- …
- Example(s):
- Counter-Example(s):
- See: Clinical Trial, Clinical Trial Phase, Pragmatic Clinical Trial, Explanatory Clinical Trial, Clinical Trial Participant, Clinical Trial Sponsor, Clinical Trial Protocol, Good Clinical Practice, Comparative Effectiveness Research.
References
2021a
- (Wikipedia, 2021) ⇒ https://en.wikipedia.org/wiki/Glossary_of_clinical_research#E Retrieved:2021-12-25.
- QUOTE: Efficacy
- The maximum ability of a drug or treatment to produce a result regardless of dosage. A drug passes efficacy trials if it is effective at the dose tested and against the illness for which it is prescribed. In the procedure mandated by the FDA, Phase II clinical trials gauge efficacy, and Phase III trials confirm it (NLM)
- Effectiveness. In medicine, the ability of an intervention (for example, a drug or surgery) to produce the desired beneficial effect. (NCI)
- QUOTE: Efficacy
2021b
- (Wikipedia, 2021) ⇒ https://en.wikipedia.org/wiki/Efficacy Retrieved:2021-12-25.
- QUOTE: Efficacy is the ability to perform a task to a satisfactory or expected degree. The word comes from the same roots as effectiveness, and it has often been used synonymously, although in pharmacology a distinction is now often made between efficacy and effectiveness.[1]
The word efficacy is used in pharmacology and medicine to refer both to the maximum response achievable from a pharmaceutical drug in research settings,[2] and to the capacity for sufficient therapeutic effect or beneficial change in clinical settings.
- QUOTE: Efficacy is the ability to perform a task to a satisfactory or expected degree. The word comes from the same roots as effectiveness, and it has often been used synonymously, although in pharmacology a distinction is now often made between efficacy and effectiveness.[1]
- ↑ Carl Zimmer, "Companies Say Their Vaccines Are 95% Effective. What Does That Mean? You might assume that 95 out of every 100 people vaccinated will be protected from Covid-19. But that's not how the math works". 20 November 2020. The New York Times
- ↑ Holford NH, Sheiner LB (1981). "Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models". Clinical Pharmacokinetics. 6 (6): 429–53. doi:10.2165/00003088-198106060-00002. PMID 7032803. S2CID 9337877.
2021c
- (Wikipedia, 2021) ⇒ https://en.wikipedia.org/wiki/Effectiveness Retrieved:2021-12-25.
- QUOTE: In medicine, effectiveness relates to how well a treatment works in practice, especially as shown in pragmatic clinical trials, as opposed to efficacy, which measures how well it works in explanatory clinical trials or research laboratory studies.
2018
- https://www.gavi.org/vaccineswork/what-difference-between-efficacy-and-effectiveness
- QUOTE: What are the differences between efficacy and effectiveness?
Efficacy is the degree to which a vaccine prevents disease, and possibly also transmission, under ideal and controlled circumstances – comparing a vaccinated group with a placebo group. Effectiveness meanwhile refers to how well it performs in the real world. Although a vaccine that has high efficacy – such as Moderna’s COVID-19 vaccine with 94.5% efficacy and Pfizer’s with 90% efficacy – would be expected to be highly effective in the real world, it is unlikely to translate into the same effectiveness in practice.
- QUOTE: What are the differences between efficacy and effectiveness?