Mevalonate Pathway

A Mevalonate Pathway is a biosynthetic metabolic pathway.

• AKA: Mevalonic Acid Pathway, Isoprenoid Biosynthesis Pathway, HMG-CoA Reductase Pathway.
• Context:
  • It can typically convert Acetyl-CoA Molecules to mevalonate pathway products.
  • It can typically involve Sequential Enzymatic Reactions through mevalonate pathway enzymes.
  • It can typically produce Isopentenyl Pyrophosphate as mevalonate pathway building block.
  • It can typically branch to Multiple Biosynthetic Routes from mevalonate pathway intermediates.
  • It can typically require ATP Molecules for mevalonate pathway phosphorylation steps.
  • ...
  • It can often support Cholesterol Biosynthesis Processes via mevalonate pathway sterol branch.
  • It can often enable Protein Prenylation through mevalonate pathway isoprenoid products.
  • It can often provide Dolichol Synthesis for mevalonate pathway glycosylation support.
  • It can often undergo Coordinate Regulation with mevalonate pathway gene expression.
  • ...
  • It can range from being a Minimal Mevalonate Pathway to being an Extended Mevalonate Pathway, depending on its mevalonate pathway branch complexity.
  • It can range from being a Constitutive Mevalonate Pathway to being an Inducible Mevalonate Pathway, depending on its mevalonate pathway regulation state.
  • ...
  • It can utilize HMG-CoA Reductase Enzymes as mevalonate pathway rate-limiting enzyme.
  • It can connect to Cholesterol Biosynthesis Processes through mevalonate pathway farnesyl branch.
  • It can interface with Ubiquinone Synthesis Processes via mevalonate pathway polyisoprenoid route.
  • It can support Heme A Synthesis Processes through mevalonate pathway farnesyl derivatives.
  • It can enable Vitamin K2 Synthesis Processes via mevalonate pathway prenyl precursors.
  • ...
• Example(s):
  • Mevalonate Pathway Locations, such as:
    • Cytosolic Mevalonate Pathways, such as:
      • Hepatocyte Mevalonate Pathway for mevalonate pathway liver cholesterol production.
      • Macrophage Mevalonate Pathway for mevalonate pathway immune regulation.
    • Peroxisomal Mevalonate Pathways, such as:
      • Alternative Mevalonate Pathway in mevalonate pathway specialized cells.
  • Mevalonate Pathway States, such as:
    • Statin-Inhibited Mevalonate Pathway under mevalonate pathway pharmaceutical block.
    • Upregulated Mevalonate Pathway in mevalonate pathway proliferative conditions.
    • Deficient Mevalonate Pathway in mevalonate pathway genetic disorders.
  • ...
• Counter-Example(s):
  • MEP Pathways, which produce isoprenoid precursors without mevalonate intermediates.
  • Fatty Acid Synthesis Pathways, which use acetyl-CoA for lipid production without mevalonate formation.
  • Shikimate Pathways, which produce aromatic compounds rather than isoprenoid structures.
• See: Biosynthetic Metabolic Pathway, HMG-CoA Reductase Enzyme, Cholesterol Biosynthesis Process, Isoprenoid Metabolism, Metabolic Pathway.

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