Staphylokinase

Staphylokinase is a Bacterial Kinase produced by certain strains of Staphylococci; it induces Fibrinolysis by converting Plasminogen to Plasmin.

• AKA: SAK.
• Context:
  • It can cleave IgG and complement component C3b, inhibiting phagocytosis.
• Example(s):
  • Staphylococcus Aureus http://www.uniprot.org/uniprot/P68802
  • PMID 11779212: “Streptokinase (SKe) produced by Streptococcus equisimilis and staphylokinase

secreted from Staphylococcus aureus are human plasminogen activators and streptokinase (SKu), produced by Streptococcus uberis, is a bovine plasminogen activator.”

• See: Staphylococcus Aureus.

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References

• (Wikipedia, http://en.wikipedia.org/wiki/Staphylokinase
  • Staphylokinase (SAK) is a amino acid enzyme from Staphylococcus aureus. [1]It is positively regulated by the "agr" gene regulator.

It activates plasminogen to form plasmin, which digest fibrin clots. This disrupts the fibrin meshworkwhich can often form to keep an infection localized.

• • Staphylokinase also cleaves IgG and complement component C3b, inhibiting phagocytosis.
  • It is classified under EC 3.4.99.22.

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