Sucrase-Isomaltase (SI) Enzyme

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A Sucrase-Isomaltase (SI) Enzyme is a Glucosidase enzyme the is composed of 2 highly similar sucrase and isomaltase subunits.



References

2019

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2009

  • Gene Ontologyhttp://amigo.geneontology.org/cgi-bin/amigo/term-details.cgi?term=GO:0004574&session_id=7072amigo1246349584
    • Accession: GO:0004574
    • Ontology: molecular function
    • Synonyms
      • related: isomaltase activity
      • related: sucrase-isomaltase activity
      • exact: alpha-limit dextrinase activity
      • exact: dextrin 6-glucanohydrolase activity
      • exact: dextrin 6alpha-glucanohydrolase activity
      • exact: exo-oligo-1,6-glucosidase activity
      • exact: oligosaccharide alpha-1,6-glucohydrolase activity
      • exact: oligosaccharide alpha-1,6-glucosidase activity
      • broad: limit dextrinase (erroneous)
    • Definition
      • Catalysis of the hydrolysis of 1,6-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. [source: EC:3.2.1.10]
  1. Hauri HP, Quaroni A, Isselbacher KJ (October 1979). "Biogenesis of intestinal plasma membrane: posttranslational route and cleavage of sucrase-isomaltase". Proceedings of the National Academy of Sciences of the United States of America. 76 (10): 5183–6. doi:10.1073/pnas.76.10.5183. PMC 413104. PMID 291933.
  2. Sjöström H, Norén O, Christiansen L, Wacker H, Semenza G (December 1980). “A fully active, two-active-site, single-chain sucrase.isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein". The Journal of Biological Chemistry. 255 (23): 11332–8. PMID 7002920.
  3. Rodriguez IR, Taravel FR, Whelan WJ (September 1984). “Characterization and function of pig intestinal sucrase-isomaltase and its separate subunits". European Journal of Biochemistry / FEBS. 143 (3): 575–82. doi:10.1111/j.1432-1033.1984.tb08408.x. PMID 6479163.
  4. 4.0 4.1 Rodríguez D, Ramsay AJ, Quesada V, Garabaya C, Campo E, Freije JM, López-Otín C (June 2013). “Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients". Human Molecular Genetics. 22 (11): 2273–82. doi:10.1093/hmg/ddt078. PMID 23418305.
  5. Berg, J. M. et al. Biochemistry, 7th Ed. W.H. Freeman and Company: New York, 2012.