Protein-Protein Interaction (PPI) Event

A Protein-Protein Interaction (PPI) Event is a biological event between Two or more Proteins.

• Context:
  • It can be represented in a PPI Database.
  • It can be a member of a Protein Interaction Network.
  • ...
• Example(s):
  • A Yeast PPI.
  • A Human PPI.
  • An Arabidopsis PPI.
  • a ProteinOf Relation.
  • ...
• Counter-Example(s):
  • • a Protein-Disease-Association relation (PDiA) Relations.
    • a Drug-Disease-Association relation (DrDiA) Relations.
    • a Drug-Drug Interaction (DDI) Relation.
• See: Genomic Database, Protein-Protein Interaction Task, Biochemical Cascade, Interactome, Protein–Protein Interaction Investigation Method.

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References

2023

• (Wikipedia, 2023) ⇒ https://en.wikipedia.org/wiki/Protein–protein_interaction Retrieved:2023-6-22.
  • Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect. Many are physical contacts with molecular associations between chains that occur in a cell or in a living organism in a specific biomolecular context.

    Proteins rarely act alone as their functions tend to be regulated. Many molecular processes within a cell are carried out by molecular machines that are built from numerous protein components organized by their PPIs. These physiological interactions make up the so-called interactomics of the organism, while aberrant PPIs are the basis of multiple aggregation-related diseases, such as Creutzfeldt–Jakob and Alzheimer's diseases.

    PPIs have been studied with many methods and from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and molecular etiology of disease, as well as the discovery of putative protein targets of therapeutic interest.

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