Ligand

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A Ligand is a simple biomolecule (functional group) that binds to a central metal atom to form a coordination complex.



References

2023

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    • A ligand is a molecule that binds to and forms a complex with a larger biomolecule, often a protein. Ligands can be atoms, ions, or molecules, and are usually characterized by their ability to bind to a specific site on a target protein, such as an enzyme or receptor. Ligands can be endogenous (produced naturally in the body) or exogenous (introduced into the body from an external source).

      Related concepts include:

      • Agonist: a type of ligand that activates a receptor by mimicking the effects of an endogenous ligand.
      • Antagonist: a type of ligand that binds to a receptor without activating it, blocking the action of endogenous ligands or other agonists.
      • Enzyme inhibitor: a type of ligand that binds to an enzyme, blocking its activity.
      • Substrate: a type of ligand that binds to an enzyme and undergoes a chemical reaction.
      • Receptor: a large protein molecule that binds to a ligand and initiates a cellular response.

2023

  1. Burdge, J., & Overby, J. (2020). Chemistry – Atoms first (4th ed.). New York, NY: McGraw Hill. doi:9781260571349