PPLRE Corpus 7181.a.2,4-5

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Raw Text

Transport of PDIM requires MmpL7, a member of the MmpL family of RND permeases. Overexpression of the interaction domain of MmpL7 acts as a dominant negative to PDIM synthesis by poisoning the interaction between synthase and transporter. This suggests that MmpL7 acts in complex with the synthesis machinery to efficiently transport PDIM across the cell membrane.


Annotated Text

  • Transport of PDIM<NamedEntity> requires MmpL7<PROTEIN_1>, a member of the MmpL family of RND permeases.
  • Overexpression of the interaction domain of MmpL7<PROTEIN_1> acts as a dominant negative to PDIM<NamedEntity> synthesis by poisoning the interaction between synthase<PROTEIN_2> and transporter.
  • This suggests that MmpL7<PROTEIN> acts in complex with the synthesis machinery to efficiently transport PDIM<NamedEntity> across the cell membrane<LOCATION>.

Notes