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VTag is an application for identifying the type, genomic location and genomic state-change of acquired genomic aberrations described in text. The application uses a machine learning technique called conditional random fields. VTag was tested with 345 training and 200 evaluation documents pertaining to cancer genetics. Our experiments resulted in 0.8541 precision, 0.7870 recall and 0.8192 F-measure on the evaluation set.
The software is available at http://www.cis.upenn.edu/group/datamining/software_dist/biosfier/.
The core of VTag is a probability model called Conditional Random Fields (CRFs) (Lafferty et al., 2001). These models are convenient because they allow us to combine the effects of many potentially informative features and have previously been successfully used for other biomedical named entity taggers (McDonald and Pereira, 2004). CRFs model the conditional probability of a tag sequence given an observation sequence: P(T|O) where O is an observation sequence, in our case a sequence of tokens in the abstract, and T=t1,t2,...,tn is a corresponding tag sequence in which each tab labels the corresponding token with on of TYPE, LOCATION, INITIAL-STATE, ALTERED-STATE and OTHER. CRFs are log-linear models based on a set of feature functions, fi(tj,tj-1,O) that map predicates on observation/tag-transition pairs to binary values. Each feature has an associated weight, li, that measure its effect on the overall choice of tags. These models are convenient because they allow us to combine the effects of many potentially informative features. …
Given a trained model, the optimal tag sequence for new examples is found with the Viterbi algorithm (Rabiner, 1993).
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|2004 AnEntityTagger||Ryan T. McDonald|
R. Scott Winters
Peter S. White
|An Entity Tagger for Recognizing Acquired Genomic Variations in Cancer Literature||Bioinformatics Subject Area||http://bioinformatics.oxfordjournals.org/cgi/content/abstract/20/17/3249||10.1093/bioinformatics/bth350||2004|
|Author||Ryan T. McDonald +, R. Scott Winters +, Mark Mandel +, Yang Jin +, Peter S. White + and Fernando Pereira +|
|title||An Entity Tagger for Recognizing Acquired Genomic Variations in Cancer Literature +|