Molecular Class-Specific Information System

A Molecular Class-Specific Information System is an Information Retrieval System that automatically collects biological data and add it to a Protein Family Database.

• AKA: MCSIS.
• Example(s):
  • GPCRDB,
  • NucleaRDB,
• Counter-Example(s):
  • SIMBAD Astronomical Database,
• See: Biological Database, Knowledge Database , G Protein-coupled Receptor, Nuclear Hormone Receptor, Genetic Mutation.

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References

2004

• (Horn et al., 2004) ⇒ Florence Horn, Anthony L. Lau, and Fred E. Cohen. (2004). “Automated Extraction of Mutation Data from the Literature: Application of MuteXt to G protein-coupled receptors and nuclear hormone receptors.” In: Bioinformatics, 20(4).
  • QUOTE: We are involved in the Molecular Class-Specific Information System (MCSIS) project, a collaborative effort to design and automate the maintenance of protein family databases. The first two databases, the GPCRDB and NucleaRDB, are focused on G protein-coupled receptors (GPCRs) and nuclear hormone receptors (NRs), respectively. The main aim of the MCSIS project is to gather heterogeneous data from across a variety of electronic and literature sources in order to draw new inferences about the target protein families.

2001

• (Horn et al., 2001) ⇒ Florence Horn, Gerrit Vriend, Fred E. Cohen. (2001). “Collecting and Harvesting Biological Data: The GPCRDB and NucleaRDB Information Systems.” In: Nucleic Acids Research, 29(1). doi:10.1093/nar/29.1.346
  • QUOTE: Molecular class-specific information systems are among the few tools available to aid molecular scientists in managing the deluge of experimental data. The GPCRDB and the NucleaRDB are two MCSISs for G protein-coupled receptors and NRs, respectively. The interesting aspect of these two MCSISs is that they are both produced and maintained in a consistent way using software. This approach will allow us to produce MCSISs for a variety of other interesting classes of macro­molecules. The only human intervention that is needed to create an MCSIS is the initial assignment of sequences in families, subfamilies, sub-subfamilies, etc. After that, the entire update procedure is automatic.

1994

• Appel R.D., Bairoch A., Hochstrasser D.F. (1994). “A new generation of information retrieval tools for biologists: the example of the ExPASy WWW server. Trends Biochem. Sci. 19:258-260

1990

• Vriend G. (1990). “WHAT IF: a molecular modeling and drug design program.” In: J. Mol. Graph. 29.

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