NucleaRDB

A NucleaRDB is a Molecular Class-Specific Information System that automatically collects, updates and retrieves biological data on Nuclear Receptors.

• Context:
  • It integrates a Nuclear Receptor Mutation Database and MuteXt data.
• Example(s):
  • http://www.receptors.org/nucleardb/
• Counter-Example(s):
  • GPCRDB.
• See: Biological Database, Knowledge Database , Phylogenetic Tree ,G Protein-coupled Receptor, Nuclear Hormone Receptor, Genetic Mutation.

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References

2019

• (Wikipedia, 2019) ⇒ https://en.wikipedia.org/wiki/NucleaRDB Retrieved:2019-1-20.
  • The NucleaRDB is a database of nuclear receptors. It contains data about the sequences, ligand binding constants and mutations of those proteins.

2012

• (Vroling et al., 2012) ⇒ Bas Vroling, David Thorne, Philip McDermott, Henk-Jan Joosten, Teresa K. Attwood, Steve Pettifer, and Gert Vriend. (2012). “NucleaRDB: Information System for Nuclear Receptors.” In: Nucleic Acids Research, 40(D1). doi:10.1093/nar/gkr960
  • ASBTRACT: The NucleaRDB is a Molecular Class-Specific Information System that collects, combines, validates and disseminates large amounts of heterogeneous data on nuclear hormone receptors. It contains both experimental and computationally derived data. The data and knowledge present in the NucleaRDB can be accessed using a number of different interactive and programmatic methods and query systems. A nuclear hormone receptor-specific PDF reader interface is available that can integrate the contents of the NucleaRDB with full-text scientific articles. The NucleaRDB is freely available at http://www.receptors.org/nucleardb.

2004

• (Horn et al., 2004) ⇒ Florence Horn, Anthony L. Lau, and Fred E. Cohen. (2004). “Automated Extraction of Mutation Data from the Literature: Application of MuteXt to G protein-coupled receptors and nuclear hormone receptors.” In: Bioinformatics, 20(4).
  • QUOTE: We are involved in the Molecular Class-Specific Information System (MCSIS) project, a collaborative effort to design and automate the maintenance of protein family databases. The first two databases, the GPCRDB and NucleaRDB, are focused on G protein-coupled receptors (GPCRs) and nuclear hormone receptors (NRs), respectively. The main aim of the MCSIS project is to gather heterogeneous data from across a variety of electronic and literature sources in order to draw new inferences about the target protein families.

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